β-HCG Clinical Test Reference range： 0-5 IU/L

Influencing factors:

1. For those who have received treatment and diagnosis with mouse monoclonal antibody preparations, the serum and plasma may contain human anti-mouse monoclonal antibodies. Such samples can cause false increases or decreases in assays using mouse monoclonal antibodies. More other diagnostic tests or clinical symptoms are needed to correctly evaluate the patient's condition.

2. Samples from heparinized patients may be partially clotted, which may lead to erroneous results due to the presence of fibers. To prevent this phenomenon, please draw a sample before heparin treatment.

3. Be careful to avoid severe hemolysis. Hemoglobin contains heme groups, which have peroxide-like activity.

4. During sample collection and serum separation, attention should be paid to avoiding bacterial contamination as much as possible. As bacteria grow, some enzymes secreted by them may decompose proteins such as antigens and antibodies.

Clinical significance:

Human chorionic gonadotropin (HCG) is a glycoprotein secreted by the trophoblast cells of the placenta. It is composed of α and β dimer glycoproteins. The glycoprotein hormone with a molecular weight of 36,700, the α subunit is basically similar to FSH (follicle stimulating hormone), LH (luteinizing hormone) and TSH (thyroid stimulating hormone) secreted by the pituitary gland, so they can cross-react with each other, while the β subunit The structures of the bases vary. In mature women, the fertilized egg moves into the uterine cavity and implants, forming an embryo. During the process of development and growth into a fetus, the placental syncytiotrophoblast cells produce a large amount of HCG, which can be excreted into the urine through the blood circulation of the pregnant woman. When 1 to 2.5 weeks into pregnancy, HCG levels in serum and urine can rise rapidly, reaching a peak at the 8th week of pregnancy, and then drop to moderate levels by the 4th month of pregnancy, and remain until the end of pregnancy. Currently commonly used detection methods include: latex set inhibition test and hemagglutination inhibition test; radioimmunoassay (RIA); enzyme-linked immunosorbent assay (ELISA); monoclonal antibody colloidal gold test.

The examination of HCG is of great significance for the diagnosis of early pregnancy, and has certain value in the diagnosis, identification and course observation of pregnancy-related diseases, trophoblastic tumors and other diseases.

1. Increased height is seen in: early pregnancy, mole, malignant mole, choriocarcinoma, seminoma, teratoma, ectopic HCG-secreting tumors (such as gastric cancer, pancreatic cancer, lung cancer, colon cancer, liver cancer, ovary cancer, digestive system carcinoid, etc.).

2. Reduction is seen in: miscarriage, etc.

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