Reference range: Currently, enzyme-labeled immunoassay, radioimmunoassay, immunoscattering method or immunoturbidimetric method are mainly used. The principle is the same as the enzyme immunoassay. Normal value: <10mg/L, determined by the measurement method.

clinical significance

1. It is an acute-phase protein that is synthesized in the liver and binds to plasma high-density lipoprotein (HDL). It is similar to CRP and is used to evaluate the process of acute-phase reactions.

2. Under normal circumstances, the plasma content is very small. When the body is stimulated by antigens such as viruses, bacteria, mycoplasma, and chlamydia, the liver synthesizes a large amount of SAA and enters the blood. When the antigen is cleared, it decreases rapidly.

3. SSA is a sensitive parameter. It starts to rise after about 5-6 hours of inflammatory reaction, and the rising time is earlier than CRP. It rises significantly during viral infection. After the pathogen is cleared, SAA quickly returns to the normal level, so it can be used as Sensitive indicators reflecting collective infection and inflammation control.

4. It is widely used in auxiliary diagnosis of infectious diseases, prediction of coronary heart disease risk, dynamic observation of efficacy and prognosis of tumor patients, observation of transplant rejection, and observation of improvement of rheumatoid arthritis. Clinically, SAA concentration <10 mg/L is generally considered normal, which is consistent with the CRP reference range.